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In an observational study conducted in three pediatric intensive care units (PICUs) in England over a three-month period in 2019, one-sixth of patients experienced at least one side effect, where they were harmed by a drug.
The study published in the British Journal of Clinical Pharmacology included 302 patients and confirmed 62 adverse events. The estimated incidence of adverse events was 20.5 per 100 patients, and most were preventable. Medications for the central nervous system, infections, and the cardiovascular system were often involved in drug side effects.
“This multicenter study is the first of its kind in UK hospitals, and the findings may provide guidance for future remedial interventions to reduce preventable drug-related harm in this vulnerable patient population,” said lead author Anwar A. Alghamdi, Ph.D., from the University of Manchester, in the UK.
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British Journal of Clinical Pharmacology (2021). DOI: 10.1111/bcp.15150
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